Premium
Structural Correlates of the Sensorimotor Cerebellum in Parkinson's Disease and Essential Tremor
Author(s) -
Lopez Alexander M.,
Trujillo Paula,
Hernandez Adreanna B.,
Lin YaChen,
Kang Hakmook,
Landman Bennett A.,
Englot Dario J.,
Dawant Benoit M.,
Konrad Peter E.,
Claassen Daniel O.
Publication year - 2020
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.28044
Subject(s) - cerebellum , essential tremor , parkinson's disease , neuroscience , psychology , movement disorders , postural instability , cerebellar hemisphere , physical medicine and rehabilitation , medicine , pathology , disease
Abstract Background Parkinson's disease (PD) and essential tremor (ET) are commonly encountered movement disorders. Pathophysiologic processes that localize to the cerebellum are described in both. There are limited studies investigating cerebellar structural changes in these conditions, largely because of inherent challenges in the efficiency of segmentation. Methods We applied a novel multiatlas cerebellar segmentation method to T1‐weighted images in 282 PD and 111 essential tremor patients to define 26 cerebellar lobule volumes. The severity of postural and resting tremor in both populations and gait and postural instability in PD patients were defined using subscores of the UPDRS and Washington Heights‐Inwood Genetic Study motor scales. These clinical measurements were related to lobule volume size. Multiple comparisons were controlled using a false discovery rate method. Results Group differences were identified between ET and PD patients, with reductions in deep cerebellar nucleus volume in ET versus reduced lobule VI volume in PD. In ET patients, lobule VIII was negatively correlated with the severity of postural tremor. In PD patients, lobule IV was positively correlated with resting tremor and total tremor severity. We observed differences in cerebellar structure that localized to sensorimotor lobules of the cerebellum. Lobule volumes appeared to differentially relate to clinical symptoms, suggesting important clinicopathologic distinctions between these conditions. These results emphasize the role of the cerebellum in tremor symptoms and should foster future clinical and pathologic investigations of the sensorimotor lobules of the cerebellum. © 2020 International Parkinson and Movement Disorder Society