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Retina Thickness as a Marker of Neurodegeneration in Prodromal Lewy Body Disease
Author(s) -
Lee JeeYoung,
Ahn Jeeyun,
Oh Sohee,
Shin Joo Young,
Kim Yu Kyeong,
Nam Hyunwoo,
Jeon Beomseok
Publication year - 2020
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.27914
Subject(s) - neurodegeneration , rem sleep behavior disorder , parkinson's disease , neuroscience , dopamine transporter , psychology , ganglion , medicine , ophthalmology , dopaminergic , dopamine , disease
Objectives We investigated retinal change and its relationship with neurodegeneration markers in a prodromal Parkinson cohort. Methods A total of 30 patients with idiopathic rapid eye movement sleep behavior disorder were recruited. Participants underwent olfactory testing, macular optical coherence tomography, microperimetry, contrast sensitivity test, and brain N ‐(3‐[ 18 F]fluoropropyl)‐2‐carbomethoxy‐3‐(4‐iodophenyl) nortropane positron emission tomography. We measured the ganglion cell complex thicknesses and investigated its correlation with olfactory function and striatal dopamine transporter availability. A linear mixed‐effect model was applied with adjustment for multiple comparisons. Results The parafoveal ganglion‐cell‐complex thickness in this cohort lay between our healthy control and drug‐naïve Parkinson's disease group data. Idiopathic rapid eye movement sleep behavior disorder patients also had contrast sensitivity impairment as in Parkinson's disease with a nonsignificant change in macular sensitivities. Macular ganglion cell complex thickness correlated with olfactory scores and with striatal dopamine transporter availabilities. Conclusions Macular ganglion cell complex thinning may be a marker of neurodegeneration in prodromal Parkinson's disease. © 2019 International Parkinson and Movement Disorder Society