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Theta‐alpha Oscillations Characterize Emotional Subregion in the Human Ventral Subthalamic Nucleus
Author(s) -
Rappel Pnina,
Grosberg Shai,
Arkadir David,
Linetsky Eduard,
Abu Snineh Muneer,
Bick Atira S.,
Tamir Idit,
Valsky Dan,
Marmor Odeya,
Abo Foul Yasmin,
Peled Or,
Gilad Moran,
Daudi Chen,
BenNaim Shiri,
Bergman Hagai,
Israel Zvi,
Eitan Renana
Publication year - 2020
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.27910
Subject(s) - subthalamic nucleus , local field potential , neuroscience , electrophysiology , psychology , electroencephalography , deep brain stimulation , parkinson's disease , alpha (finance) , medicine , pathology , developmental psychology , construct validity , disease , psychometrics
Background Therapeutic outcomes of STN‐DBS for movement and psychiatric disorders depend on electrode location within the STN. Electrophysiological and functional mapping of the STN has progressed considerably in the past years, identifying beta‐band oscillatory activity in the dorsal STN as a motor biomarker. It also has been suggested that STN theta‐alpha oscillations, involved in impulse control and action inhibition, have a ventral source. However, STN local field potential mapping of motor, associative, and limbic areas is often limited by poor spatial resolution. Objectives Providing a high‐resolution electrophysiological map of the motor, associative and limbic anatomical sub‐areas of the subthalamic nucleus. Methods We have analyzed high‐spatial‐resolution STN microelectrode electrophysiology recordings of PD patients (n = 303) that underwent DBS surgery. The patients’ STN intraoperative recordings of spiking activity (933 electrode trajectories) were combined with their imaging data (n = 83 patients, 151 trajectories). Results We found a high theta‐alpha (7–10 Hz) oscillatory area, located near the STN ventromedial border in 29% of the PD patients. Theta‐alpha activity in this area has higher power and lower central frequency in comparison to theta‐alpha activity in more dorsal subthalamic areas. When projected on the DISTAL functional atlas, the theta‐alpha oscillatory area overlaps with the STN limbic subarea. Conclusions We suggest that theta‐alpha oscillations can serve as an electrophysiological marker for the ventral subthalamic nucleus limbic subarea. Therefore, theta‐alpha oscillations can guide optimal electrode placement in neuropsychiatric STN‐DBS procedures and provide a reliable biomarker input for future closed‐loop DBS device. © 2019 International Parkinson and Movement Disorder Society