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How to apply the movement disorder society criteria for diagnosis of progressive supranuclear palsy
Author(s) -
Grimm MaxJoseph,
Respondek Gesine,
Stamelou Maria,
Arzberger Thomas,
Ferguson Leslie,
Gelpi Ellen,
Giese Armin,
Grossman Murray,
Irwin David J.,
Pantelyat Alexander,
Rajput Alex,
Roeber Sigrun,
Swieten John C.,
Troakes Claire,
Antonini Angelo,
Bhatia Kailash P.,
Colosimo Carlo,
Eimeren Thilo,
Kassubek Jan,
Levin Johannes,
Meissner Wassilios G.,
Nilsson Christer,
Oertel Wolfgang H.,
Piot Ines,
Poewe Werner,
Wenning Gregor K.,
Boxer Adam,
Golbe Lawrence I.,
Josephs Keith A.,
Litvan Irene,
Morris Huw R.,
Whitwell Jennifer L.,
Compta Yaroslau,
Corvol JeanChristophe,
Lang Anthony E.,
Rowe James B.,
Höglinger Günter U.
Publication year - 2019
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.27666
Subject(s) - progressive supranuclear palsy , cohort , movement disorders , palsy , pediatrics , psychology , medicine , disease , pathology , alternative medicine
Background The Movement Disorder Society criteria for progressive supranuclear palsy define diagnostic allocations, stratified by certainty levels and clinical predominance types. We aimed to study the frequency of ambiguous multiple allocations and to develop rules to eliminate them. Methods We retrospectively collected standardized clinical data by chart review in a multicenter cohort of autopsy‐confirmed patients with progressive supranuclear palsy, to classify them by diagnostic certainty level and predominance type and to identify multiple allocations. Results Comprehensive data were available from 195 patients. More than one diagnostic allocation occurred in 157 patients (80.5%). On average, 5.4 allocations were possible per patient. We developed four rules for Multiple Allocations eXtinction (MAX). They reduced the number of patients with multiple allocations to 22 (11.3%), and the allocations per patient to 1.1. Conclusions The proposed MAX rules help to standardize the application of the Movement Disorder Society criteria for progressive supranuclear palsy. © 2019 International Parkinson and Movement Disorder Society