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Widespread microglial activation in multiple system atrophy
Author(s) -
Kübler Dorothee,
Wächter Tobias,
Cabanel Nicole,
Su Zhangjie,
Turkheimer Federico E.,
Dodel Richard,
Brooks David J.,
Oertel Wolfgang H.,
Gerhard Alexander
Publication year - 2019
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.27620
Subject(s) - putamen , precentral gyrus , atrophy , caudate nucleus , medicine , orbitofrontal cortex , pathology , neuroscience , population , cingulate cortex , microglia , movement disorders , psychology , central nervous system , prefrontal cortex , disease , magnetic resonance imaging , cognition , inflammation , environmental health , radiology
Background The pattern and role of microglial activation in multiple system atrophy is largely unclear. The objective of this study was to use [ 11 C] (R) ‐PK11195 PET to determine the extent and correlation of activated microglia with clinical parameters in MSA patients. Methods Fourteen patients with the parkinsonian phenotype of MSA (MSA‐P) with a mean disease duration of 2.9 years (range 2‐5 years) were examined with [ 11 C] (R) ‐PK11195 PET and compared with 10 healthy controls. Results Patients with the parkinsonian phenotype of MSA showed a significant ( P ≤ 0.01) mean increase in binding potentials compared with healthy controls in the caudate nucleus, putamen, pallidum, precentral gyrus, orbitofrontal cortex, presubgenual anterior cingulate cortex, and the superior parietal gyrus. No correlations between binding potentials and clinical parameters were found. Conclusions In early clinical stages of the parkinsonian phenotype of MSA, there is widespread microglial activation as a marker of neuroinflammatory changes without correlation to clinical parameters in our patient population. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.