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Glucocerebrosidase mutations and synucleinopathies: Toward a model of precision medicine
Author(s) -
Blandini Fabio,
Cilia Roberto,
Cerri Silvia,
Pezzoli Gianni,
Schapira Anthony H.V.,
Mullin Stephen,
Lanciego José L.
Publication year - 2019
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.27583
Subject(s) - synucleinopathies , glucocerebrosidase , dementia with lewy bodies , parkinson's disease , lewy body , dementia , phenotype , neuroscience , alpha synuclein , disease , medicine , biology , gene , genetics
Abstract Glucocerebrosidase is a lysosomal enzyme. The characterization of a direct link between mutations in the gene coding for glucocerebrosidase ( GBA1 ) with the development of Parkinson's disease and dementia with Lewy bodies has heightened interest in this enzyme. Although the mechanisms through which glucocerebrosidase regulates the homeostasis of α‐synuclein remains poorly understood, the identification of reduced glucocerebrosidase activity in the brains of patients with PD and dementia with Lewy bodies has paved the way for the development of novel therapeutic strategies directed at enhancing glucocerebrosidase activity and reducing α‐synuclein burden, thereby slowing down or even preventing neuronal death. Here we reviewed the current literature relating to the mechanisms underlying the cross talk between glucocerebrosidase and α‐synuclein, the GBA1 mutation‐associated clinical phenotypes, and ongoing therapeutic approaches targeting glucocerebrosidase. © 2018 International Parkinson and Movement Disorder Society