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Electroencephalography‐based machine learning for cognitive profiling in Parkinson's disease: Preliminary results
Author(s) -
Betrouni Nacim,
Delval Arnaud,
Chaton Laurence,
Defebvre Luc,
Duits Annelien,
Moonen Anja,
Leentjens Albert F.G.,
Dujardin Kathy
Publication year - 2019
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.27528
Subject(s) - electroencephalography , cognition , support vector machine , parkinson's disease , artificial intelligence , disease , psychology , computer science , machine learning , pattern recognition (psychology) , physical medicine and rehabilitation , medicine , psychiatry , pathology
Background Cognitive symptoms are common in patients with Parkinson's disease. Characterization of a patient's cognitive profile is an essential step toward the identification of predictors of cognitive worsening. Objective The aim of this study was to investigate the use of the combination of resting‐state EEG and data‐mining techniques to build characterization models. Methods Dense EEG data from 118 patients with Parkinson's disease, classified into 5 different groups according to the severity of their cognitive impairments, were considered. Spectral power analysis within 7 frequency bands was performed on the EEG signals. The obtained quantitative EEG features of 100 patients were mined using 2 machine‐learning algorithms to build and train characterization models, namely, support vector machines and k‐nearest neighbors models. The models were then blindly tested on data from 18 patients. Results The overall classification accuracies were 84% and 88% for the support vector machines and k‐nearest algorithms, respectively. The worst classifications were observed for patients from groups with small sample sizes, corresponding to patients with the severe cognitive deficits. Whereas for the remaining groups for whom an accurate diagnosis was required to plan the future healthcare, the classification was very accurate. Conclusion These results suggest that EEG features computed from a daily clinical practice exploration modality in—that it is nonexpensive, available anywhere, and requires minimal cooperation from the patient—can be used as a screening method to identify the severity of cognitive impairment in patients with Parkinson's disease. © 2018 International Parkinson and Movement Disorder Society