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Deep brain stimulation treated dystonia‐trajectory via status dystonicus
Author(s) -
Nerrant Elodie,
Gonzalez Victoria,
Milesi Christophe,
Vasques Xavier,
Ruge Diane,
Roujeau Thomas,
De Antonio Rubio Isabel,
Cyprien Fabienne,
Seng Emilie Chan,
Demailly Diane,
Roubertie Agathe,
Boularan Alain,
Greco Fréderic,
Perrigault PierreFrançois,
Cambonie Gilles,
Coubes Philippe,
Cif Laura
Publication year - 2018
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.27357
Subject(s) - dystonia , deep brain stimulation , demographics , cohort , pediatrics , movement disorders , medicine , parkinson's disease , psychology , disease , physical medicine and rehabilitation , neuroscience , demography , sociology
ABSTRACT Background : Status dystonicus (SD) is a life‐threatening condition. Objective and Methods : In a dystonia cohort who developed status dystonicus, we analyzed demographics, background dystonia phenomenology and complexity, trajectory previous to‐, via status dystonicus episodes, and evolution following them. Results : Over 20 years, 40 of 328 dystonia patients who were receiving DBS developed 58 status dystonicus episodes. Dystonia was of pediatric onset (95%), frequently complex, and had additional cognitive and pyramidal impairment (62%) and MRI alterations (82.5%); 40% of episodes occured in adults. Mean disease duration preceding status dystonicus was 10.3 ± 8 years. Evolution time to status dystonicus varied from days to weeks; however, 37.5% of patients exhibited progressive worsening over years. Overall, DBS was efficient in resolving 90% of episodes. Conclusion : Status dystonicus is potentially reversible and a result of heterogeneous conditions with nonuniform underlying physiology. Recognition of the complex phenomenology, morphological alterations, and distinct patterns of evolution, before and after status dystonicus, will help our understanding of these conditions. © 2018 International Parkinson and Movement Disorder Society