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Lifetime exposure to estrogen and progressive supranuclear palsy: Environmental and Genetic PSP study
Author(s) -
Park Hee Kyung,
Ilango Sindana,
Charriez Christina M.,
Checkoway Harvey,
Riley David,
Standaert David G.,
Bordelon Yvette,
Shprecher David R.,
Reich Stephen G.,
Hall Deborah,
Kluger Benzi,
Marras Connie,
Jankovic Joseph,
Dubinsky Richard,
Litvan Irene
Publication year - 2018
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.27336
Subject(s) - progressive supranuclear palsy , estrogen , odds ratio , medicine , menarche , confidence interval , logistic regression , case control study , oncology , psychology , disease , physiology
Background Studies suggesting a protective effect of estrogen in neurodegenerative diseases prompted us to investigate this relationship in progressive supranuclear palsy (PSP).Methods This case‐control study evaluated the self‐reported reproductive characteristics and estrogen of 150 women with PSP and 150 age‐matched female controls who participated in the Environmental Genetic‐PSP study. Conditional logistic regression models were generated to examine associations of PSP with estrogen.Results There was no association between years of estrogen exposure duration and PSP. There was a suggestion of an inverse association between composite estrogen score and PSP that did not reach statistical significance ( P = .06). Any exposure to estrogen replacement therapy halved the risk of PSP (odds ratio = 0.52; 95% confidence interval = 0.30‐0.92; P = .03). Among PSP cases, earlier age at menarche was associated with better performance on Hoehn and Yahr stage (β = −0.60; SE = 0.26; P = .02) and Unified Parkinson's Disease Rating Scale II score (β = −5.19; SE = 2.48; P = .04) at clinical examination.Conclusions This case‐control study suggests a protective role of lifetime estrogen exposure in PSP. Future studies will be needed to confirm this association. © 2018 International Parkinson and Movement Disorder Society