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Are the MDS‐UPDRS–Based Composite Scores Clinically Applicable?
Author(s) -
Makkos Attila,
Kovács Márton,
Aschermann Zsuzsanna,
Harmat Márk,
Janszky József,
Karádi Kázmér,
Kovács Norbert
Publication year - 2018
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.27303
Subject(s) - rating scale , movement disorders , physical therapy , medicine , psychology , physical medicine and rehabilitation , disease , developmental psychology
Background: The International Parkinson and Movement Disorder Society–sponsored UPDRS (MDS‐UPDRS) is a powerful clinical outcome measure. Objectives: To evaluate the feasibility of various MDS‐UPDRS‐based composite scores and determine their minimal clinically important difference threshold values. Methods: Overall, 1,113 paired investigations of 452 patients were reviewed implementing three different techniques simultaneously. Results: Based on the ordinal regression modeling, the MDS‐UPDRS II+III, MDS‐UPDRS I+II+III, and the total score of MDS‐UPDRS are clinically applicable outcome measures. Any improvement greater than 4.9 points or any worsening more than 4.2 points on MDS‐UPDRS II+III represent a minimal, yet clinically meaningful, change. In reference to MDS‐UPDRS I+II+III, the smallest changes considered clinically relevant were 6.7 and 5.2 points for improvement and deterioration, respectively. The thresholds for the total score of MDS‐UPDRS were 7.1 points for improvement and 6.3 points for worsening. Conclusions: Our findings support the application of various MDS‐UPDRS–based composite scores. © 2018 International Parkinson and Movement Disorder Society