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The emerging role of Rab GTPases in the pathogenesis of Parkinson's disease
Author(s) -
Gao Yujing,
Wilson Gabrielle R.,
Stephenson Sarah E. M.,
Bozaoglu Kiymet,
Farrer Matthew J.,
Lockhart Paul J.
Publication year - 2018
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.27270
Subject(s) - rab , gtpase , lrrk2 , pathogenesis , biology , microbiology and biotechnology , guanine nucleotide exchange factor , neuroscience , disease , parkinson's disease , medicine , immunology , pathology
The identification of pathogenic mutations in Ras analog in brain 39B ( RAB39B ) and Ras analog in brain 32 ( RAB32 ) that cause Parkinson's disease (PD) has highlighted the emerging role of protein trafficking in disease pathogenesis. Ras analog in brain (Rab) Guanosine triphosphatase (GTPase) function as master regulators of membrane trafficking, including vesicle formation, movement along cytoskeletal networks, and membrane fusion. Recent studies have linked Rab GTPases with α‐synuclein, Leucine‐rich repeat kinase 2, and Vacuolar protein sorting 35, 3 key proteins in PD pathogenesis. In this review, we discuss the various RAB GTPases associated with PD, current progress in the research, and potential future directions. Investigations into the function of RAB GTPases will likely provide significant insight into the etiology of PD and identify novel therapeutic targets for a currently incurable disease. © 2018 International Parkinson and Movement Disorder Society