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Tonsillectomy and risk of Parkinson's disease: A danish nationwide population‐based cohort study
Author(s) -
Svensson Elisabeth,
Henderson Victor W.,
Szépligeti Szimonetta,
Stokholm Morten Gersel,
Klug Tejs Ehlers,
Sørensen Henrik Toft,
Borghammer Per
Publication year - 2018
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.27253
Subject(s) - medicine , hazard ratio , confidence interval , cohort , population , proportional hazards model , tonsillectomy , cohort study , pediatrics , surgery , environmental health
Background : We hypothesized that tonsillectomy modifies the risk of PD. Objectives: To test the hypothesis in a nationwide population‐based cohort study. Methods: We used Danish medical registries to construct a cohort of all patients in Denmark with an operation code of tonsillectomy 1980‐2010 (n = 195,169) and a matched age and sex general population comparison cohort (n = 975,845). Patients were followed until PD diagnosis, death, censoring, or end of follow‐up 30 November 2013. Using Cox regression, we computed hazard ratios for PD and corresponding 95% confidence intervals, adjusting for age and sex by study design, and potential confounders. Results: We identified 100 and 568 patients diagnosed with PD among the tonsillectomy and general population comparison cohort, respectively, finding similar risks of PD (adjusted hazard ratio = 0.95 [95% confidence interval: 0.76‐1.19]; for > 20 years' follow‐up (adjusted hazard ratio = 0.96 [95% confidence interval: 0.64‐1.41]). Conclusion: Tonsillectomy is not associated with risk of PD, especially early‐onset PD. © 2017 International Parkinson and Movement Disorder Society
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