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Subcortical shape analysis of progressive mild cognitive impairment in Parkinson's disease
Author(s) -
Chung Su Jin,
Shin JeongHyeon,
Cho Kyoo Ho,
Lee Yoonju,
Sohn Young H.,
Seong JoonKyung,
Lee Phil Hyu
Publication year - 2017
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.27106
Subject(s) - thalamus , parkinson's disease , dementia , psychology , cognition , verbal fluency test , neuroscience , effects of sleep deprivation on cognitive performance , audiology , cardiology , medicine , neuropsychology , disease
Background Cortical neural correlates of ongoing cognitive decline in Parkinson's disease (PD) have been suggested; however, the role of subcortical structures in longitudinal change of cognitive dysfunction in PD has not been fully investigated. Here, we used automatic analysis to explore subcortical brain structures in patients with PD with mild cognitive impairment that converts into PD with dementia. Methods One hundred eighty‐two patients with PD with mild cognitive impairment were classified as PD with mild cognitive impairment converters (n = 74) or nonconverters (n = 108), depending on whether they were subsequently diagnosed with dementia in PD. We used surface‐based analysis to compare atrophic changes of subcortical brain structures between PD with mild cognitive impairment converters and nonconverters. Results PD with mild cognitive impairment converters had lower cognitive composite scores in the attention and frontal executive domains than did nonconverters. Subcortical shape analysis revealed that PD with mild cognitive impairment converters had smaller local shape volumes than did nonconverters in the bilateral thalamus, right caudate, and right hippocampus. Logistic regression analysis showed that local shape volumes in the bilateral thalamus and right caudate were significant independent predictors of PD with mild cognitive impairment converters. In the PD with mild cognitive impairment converter group, thalamic local shape volume was associated with semantic fluency and attentional composite score. Conclusions The present data suggest that the local shape volumes of deep subcortical structures, especially in the caudate and thalamus, may serve as important predictors of the development of dementia in patients with PD. © 2017 International Parkinson and Movement Disorder Society