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Thalamic deep brain stimulation for orthostatic tremor: A multicenter international registry
Author(s) -
Merola Aristide,
Fasano Alfonso,
Hassan Anhar,
Ostrem Jill L.,
Contarino Maria Fiorella,
Lyons Mark,
Krauss Joachim K.,
Wolf Marc E.,
Klassen Bryan T.,
van Rootselaar AnneFleur,
Regidor Ignacio,
Duker Andrew P.,
Ondo William,
Guridi Jorge,
Volkmann Jens,
Wagle Shukla Aparna,
Mandybur George T.,
Okun Michael S.,
Witt Karsten,
Starr Philip A.,
Deuschl Günther,
Espay Alberto J.
Publication year - 2017
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.27082
Subject(s) - medicine , activities of daily living , deep brain stimulation , stimulation , physical medicine and rehabilitation , orthostatic vital signs , refractory (planetary science) , physical therapy , anesthesia , psychology , parkinson's disease , physics , disease , astrobiology , blood pressure
Background We report the accumulated experience with ventral intermediate nucleus deep brain stimulation for medically refractory orthostatic tremor. Methods Data from 17 patients were reviewed, comparing presurgical, short‐term (0‐48 months), and long‐term (≥48 months) follow‐up. The primary end point was the composite activities of daily living/instrumental activities of daily living score. Secondary end points included latency of symptoms on standing and treatment‐related complications. Results There was a 21.6% improvement ( P = 0.004) in the composite activities of daily living/instrumental activities of daily living score, which gradually attenuated (12.5%) in the subgroup of patients with an additional long‐term follow‐up (8 of 17). The latency of symptoms on standing significantly improved, both in the short‐term ( P = 0.001) and in the long‐term ( P = 0.018). Three patients obtained no/minimal benefit from the procedure. Conclusions Deep brain stimulation of the ventral intermediate nucleus was, in general, safe and well tolerated, yielding sustained benefit in selected patients with medically refractory orthostatic tremor. © 2017 International Parkinson and Movement Disorder Society