Premium
In V ivo cortical tau in Parkinson's disease using 18F‐AV‐1451 positron emission tomography
Author(s) -
Hansen Allan K.,
Damholdt Malene Flensborg,
Fedorova Tatyana D.,
Knudsen Karoline,
Parbo Peter,
Ismail Rola,
Østergaard Karen,
Brooks David J.,
Borghammer Per
Publication year - 2017
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.26961
Subject(s) - cognitive impairment , neuropsychology , positron emission tomography , cognition , parkinson's disease , medicine , stage (stratigraphy) , dementia , psychology , disease , neuroscience , pathology , nuclear medicine , paleontology , biology
Background: Alzheimer's disease copathology is common in PD at autopsy. In non‐PD subjects with mild cognitive impairment, tau depositions can be detected using 18F‐AV‐1451 PET. We hypothesized that 18F‐AV‐1451 PET would show tau aggregation in PD with mild cognitive impairment and correlate with cognitive dysfunction. Objectives: To describe tau aggregation in PD patients. Methods: Twenty‐six PD patients and 23 controls had 18F‐AV‐1451 PET and neuropsychological assessment to detect mild cognitive impairment. Results: Nine PD patients (35%) were identified with mild cognitive impairment. Regional analyses showed no significant differences between groups. Voxel‐wise analyses showed no correlation with cognitive domain z‐scores within patients. One patient with mild cognitive impairment was estimated Braak tau stage 5; all other patients were stage 0. Conclusion: Our results indicate that tau pathology, as detected by 18F‐AV‐1451, is uncommon in PD with mild cognitive impairment and shows no significant correlation with cognitive dysfunction at this stage. © 2017 International Parkinson and Movement Disorder Society