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Mortality risk in a nationwide cohort of individuals with tic disorders and with tourette syndrome
Author(s) -
Meier Sandra M.,
Dalsgaard Søren,
Mortensen Preben B.,
Leckman James F.,
Plessen Kerstin J.
Publication year - 2017
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.26939
Subject(s) - tourette syndrome , medicine , tics , psychiatry , cohort study , tic disorder , mortality rate , standardized mortality ratio , cohort , prospective cohort study , rate ratio , pediatrics , substance abuse , confidence interval
Background : Few studies have investigated mortality risk in individuals with tic disorders. Methods : We thus measured the risk of premature death in individuals with tic disorders and with Tourette syndrome in a prospective cohort study with 80 million person‐years of follow‐up. We estimated mortality rate ratios and adjusted for calendar year, age, sex, urbanicity, maternal and paternal age, and psychiatric disorders to compare individuals with and without tic disorders. Results : The risk of premature death was higher among individuals with tic disorders (mortality rate ratio, 2.02; 95% CI, 1.49‐2.66) and with Tourette syndrome (mortality rate ratio, 1.63; 95% CI, 1.11‐2.28) compared with controls. After the exclusion of individuals with comorbid attention‐deficit/hyperactivity disorder, obsessive‐compulsive disorder, and substance abuse, tic disorder remained associated with increased mortality risk (mortality rate ratio, 2.30; 95% CI, 1.57‐3.23), as did also Tourette Syndrome (mortality rate ratio, 1.81; 95% CI, 1.11–2.75). Conclusions : These results are of clinical significance for clinicians and advocacy organizations. Several factors may contribute to this increased risk of premature death, and more research mapping out these factors is needed. © 2017 International Parkinson and Movement Disorder Society