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Familial aggregation of Parkinson's disease may affect progression of motor symptoms and dementia
Author(s) -
Gaare Johannes Jernqvist,
Skeie Geir Olve,
Tzoulis Charalampos,
Larsen Jan Petter,
Tysnes OleBjørn
Publication year - 2017
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.26856
Subject(s) - cohort , dementia , family aggregation , endophenotype , family history , medicine , population , relative risk , disease , parkinson's disease , first degree relatives , cohort study , psychology , psychiatry , confidence interval , cognition , environmental health
ABSTRACT Background Familial aggregation has been described in PD of both early and late onset, but has not been studied in a true population‐based sample. Moreover, little is known about its association with disease progression and endophenotypes. Objectives The objectives of this work were to determine familial aggregation of idiopathic PD in a population‐based cohort and study the association with clinical endophenotypes and disease progression. Methods We examined family history data from the Norwegian ParkWest study, a well‐characterized, population‐based cohort of incident PD patients and age‐matched healthy controls. Family data were collected at baseline with a simplified questionnaire (192 cases and 193 controls) and after 3 years of longitudinal follow‐up using an extended questionnaire (172 cases and 171 controls). Results Compared to the controls, the PD patients had an increased relative risk of having a first‐degree relative with PD when using the extended questionnaire (relative risk = 1.988; P = 0.036), but not when using the simplified questionnaire (relative risk = 1.453; P = 0.224). There was no significant difference in age of onset or motor subtype ( P = 0.801). However, cases with a family history of PD had reduced progression over 7 years as measured by UPDRS II ( P = 0.008) and smaller rate of decrease of MMSE ( P = 0.046). Conclusions Our findings confirm familial aggregation in a population‐based cohort of idiopathic PD. Moreover, we show that positive family history of PD in patients is associated with a slower progression of PD symptoms and cognitive decline. © 2016 International Parkinson and Movement Disorder Society