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Motor features in Parkinson's disease with normal olfactory function
Author(s) -
Rossi Malco,
Escobar Alex Medina,
Bril Andrea,
Millar Vernetti Patricio,
Palo Juan Ignacio,
Cerquetti Daniel,
Merello Marcelo
Publication year - 2016
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.26687
Subject(s) - parkinson's disease , olfactory system , neuroscience , motor function , medicine , physical medicine and rehabilitation , disease , biology , pathology
Background Normosmic Parkinson's disease (PD) might be a unique clinical phenotype with a more benign course when compared with hyposmic PD. Objective The objective of this study was to evaluate motor features and the acute levodopa response according to olfactory function. Methods A total of 169 de novo PD patients that underwent olfactory testing and acute levodopa challenge for clinical prediction of sustained long‐term dopaminergic response were evaluated. Results The overall frequency of normosmia was 33%. Normosmic PD patients scored nonsignificantly different to hyposmic/anosmic patients on motor scale and on degree of improvement with levodopa. Motor scores at follow‐up were comparable among groups. Conclusions Normal olfactory function is common in early PD and was not associated with a different motor phenotype when compared with PD patients with olfactory dysfunction. © 2016 International Parkinson and Movement Disorder Society