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REM sleep behavior disorder, as assessed by questionnaire, in G2019S LRRK2 mutation PD and carriers
Author(s) -
SaundersPullman Rachel,
Alcalay Roy N.,
Mirelman Anat,
Wang Cuiling,
Luciano Marta San,
Ortega Roberto A.,
Glickman Amanda,
Raymond Deborah,
MejiaSantana Helen,
Doan Nancy,
Johannes Brooke,
Yasinovsky Kira,
Ozelius Laurie,
Clark Lorraine,
OrrUtreger Avi,
Marder Karen,
Giladi Nir,
Bressman Susan B.
Publication year - 2015
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.26413
Subject(s) - lrrk2 , parkinson's disease , rapid eye movement sleep , rem sleep behavior disorder , medicine , odds ratio , movement disorders , gastroenterology , disease , psychology , eye movement , ophthalmology
Background Rapid eye movement sleep behavior disorder occurs with idiopathic Parkinson's disease (PD) and often precedes PD. Its frequency in LRRK2 ‐PD and utility as a preclinical marker has not been established. Methods One hundred forty‐four idiopathic PD, 142 LRRK2 G2019S mutation PD, 117 non‐manifesting carriers, 93 related noncarriers, and 40 healthy controls completed the Rapid eye movement sleep Behavior Disorder Screening Questionnaire. Results Cut scores were met by 30.6% idiopathic PD, 19.7% LRRK2 ‐PD, 6% nonmanifesting carriers, 20.4% related noncarriers, and 15% controls. The likelihood of abnormal scores was decreased in LRRK2 ‐PD versus idiopathic PD (odds ratio = 0.55, P = 0.03), nonmanifesting carriers versus related noncarriers (OR = 0.25, P < 0.01), and PD of less than 3 years' duration, 1 of 19 LRRK2 ‐PD versus 14 of 41 idiopathic PD ( P < 0.05). Conclusions A lower frequency of abnormal questionnaire scores is seen in LRRK2 ‐PD, especially in early LRRK2 ‐PD, and in nonmanifesting carriers. Therefore, the Rapid eye movement sleep Behavior Disorder Questionnaire is unlikely to serve as a preclinical marker for phenoconversion to PD. © 2015 International Parkinson and Movement Disorder Society