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Premotor–motor excitability is altered in dopa‐responsive dystonia
Author(s) -
Weissbach Anne,
Bäumer Tobias,
Brüggemann Norbert,
Tadic Vera,
Zittel Simone,
Cheng Bastian,
Thomalla Götz,
Klein Christine,
Münchau Alexander
Publication year - 2015
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.26365
Subject(s) - dystonia , transcranial magnetic stimulation , neuroscience , silent period , levodopa , dopaminergic , motor cortex , premotor cortex , psychology , parkinsonism , stimulation , medicine , parkinson's disease , dopamine , anatomy , disease , dorsum
Background Dopa‐responsive dystonia is clinically dominated by a combination of dystonia and parkinsonism, both known to be associated with abnormal activity in premotor‐motor circuits. Methods To probe premotor‐motor excitability, we used a transcranial magnetic stimulation dual pulse conditioning paradigm in 15 genetically confirmed dopa‐responsive dystonia patients and 20 controls under different medication states. We also determined silent periods, short‐latency afferent inhibition, interhemispheric inhibition, and short‐interval intracortical inhibition and facilitation. Results In contrast to healthy controls, no motor cortex inhibition was seen after premotor conditioning regardless of the dopaminergic state in patients. The duration of the ipsilateral silent period was increased in the OFF state, and short‐latency afferent inhibition was reduced in the ON compared with the OFF state. Conclusion Premotor‐motor circuits appear hyporesponsive in dopa‐responsive dystonia. © 2015 International Parkinson and Movement Disorder Society