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Development and initial testing of the Penn Parkinson's Daily Activities Questionnaire
Author(s) -
Brennan Laura,
Siderowf Andrew,
Rubright Jonathan D.,
Rick Jacqueline,
Dahodwala Nabila,
Duda John E.,
Hurtig Howard,
Stern Matthew,
Xie Sharon X.,
Rennert Lior,
Karlawish Jason,
Shea Judy A.,
Trojanowski John Q.,
Weintraub Daniel
Publication year - 2016
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.26339
Subject(s) - psychology , parkinson's disease , medicine , physical medicine and rehabilitation , disease
Objective The aim of this work was to describe the development and psychometric analysis of the Penn Parkinson's Daily Activities Questionnaire. The questionnaire is an item response theory‐based tool for rating cognitive instrumental activities of daily living in PD. Methods Candidate items for the Penn Parkinson's Daily Activities Questionnaire were developed through literature review and focus groups of patients and knowledgeable informants. Item selection and calibration of item‐response theory parameters were performed using responses from a cohort of PD patients and knowledgeable informants (n = 388). In independent cohorts of PD patients and knowledgeable informants, assessments of test‐retest reliability (n = 50), and construct validity (n = 68) of the questionnaire were subsequently performed. Construct validity was assessed by correlating questionnaire scores with measures of motor function, cognition, an existing activities of daily living measure, and directly observed daily function. Results Fifty items were retained in the final questionnaire item bank. Items were excluded owing to redundancy, difficult reading level, and when item‐response theory parameters could not be calculated. Test‐retest reliability was high (intraclass correlation coefficient = 0.97; P < 0.001). The questionnaire correlated strongly with cognition (r = 0.68; P < 0.001) and directly observed daily function (r = 0.87; P < 0.001), but not with motor impairment (r = 0.08; P = 0.53). The questionnaire score accurately discriminated between PD patients with and without dementia (receiver operating characteristic curve = 0.91; 95% confidence interval: 0.85–0.97). Conclusions The Penn Parkinson's Daily Activities Questionnaire shows strong evidence of reliability and validity. Item response theory‐based psychometric analysis suggests that this questionnaire can discriminate across a range of daily functions. © 2015 International Parkinson and Movement Disorder Society