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Modifications of resting state networks in spinocerebellar ataxia type 2
Author(s) -
Cocozza Sirio,
Saccà Francesco,
Cervo Amedeo,
Marsili Angela,
Russo Cinzia Valeria,
Giorgio Sara Maria delle Acque,
De Michele Giuseppe,
Filla Alessandro,
Brunetti Arturo,
Quarantelli Mario
Publication year - 2015
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.26284
Subject(s) - spinocerebellar ataxia , default mode network , resting state fmri , atrophy , neuroscience , white matter , voxel , magnetic resonance imaging , psychology , functional magnetic resonance imaging , cardiology , ataxia , medicine , radiology
Purpose We aimed to investigate the integrity of the Resting State Networks in spinocerebellar ataxia type 2 (SCA2) and the correlations between the modification of these networks and clinical variables. Methods Resting‐state functional magnetic resonance imaging (RS‐fMRI) data from 19 SCA2 patients and 29 healthy controls were analyzed using an independent component analysis and dual regression, controlling at voxel level for the effect of atrophy by co‐varying for gray matter volume. Correlations between the resting state networks alterations and disease duration, age at onset, number of triplets, and clinical score were assessed by Spearman's coefficient, for each cluster which was significantly different in SCA2 patients compared with healthy controls. Results In SCA2 patients, disruption of the cerebellar components of all major resting state networks was present, with supratentorial involvement only for the default mode network. When controlling at voxel level for gray matter volume, the reduction in functional connectivity in supratentorial regions of the default mode network, and in cerebellar regions within the default mode, executive and right fronto‐parietal networks, was still significant. No correlations with clinical variables were found for any of the investigated resting state networks. Conclusions The SCA2 patients show significant alterations of the resting state networks, only partly explained by the atrophy. The default mode network is the only resting state network that shows also supratentorial changes, which appear unrelated to the cortical gray matter volume. Further studies are needed to assess the clinical significance of these changes. © 2015 International Parkinson and Movement Disorder Society