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Olfactory D ysfunction E valuation I s N ot A ffected by C omorbid D epression in P arkinson's D isease
Author(s) -
Rossi Malco,
PerezLloret Santiago,
Millar Vernetti Patricio,
Drucaroff Lucas,
Costanzo Elsa,
Ballesteros Diego,
Bril Andrea,
Cerquetti Daniel,
Guinjoan Salvador,
Merello Marcelo
Publication year - 2015
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.26276
Subject(s) - parkinson's disease , depression (economics) , medicine , degenerative disease , disease , psychology , neuroscience , psychiatry , central nervous system disease , economics , macroeconomics
Background Olfactory function assessment is an important screening tool for Parkinson's disease (PD) diagnosis. It is debated whether olfaction is affected by comorbid depression. We assessed the relationship between depression and olfaction in PD and determined whether depression may limit the usefulness of olfactory testing for PD diagnosis. Methods Olfaction was evaluated using the Sniffin' Sticks test and the Hyposmia Rating Scale in four groups of subjects: PD patients without depression (n = 30); PD patients with major depression (PDD; n = 30); major depressive disorder (MDD) patients (n = 29); and healthy controls (HCs; n = 30). Results No differences were found between PD and PDD patients for total Sniffin' Sticks test, threshold, discrimination or identification scores, or in Hyposmia Rating Scale, although both groups differed from HCs and MDD patients ( P < 0.05), which, in turn, showed similar olfactory scores. Conclusions Lack of differences in olfactory impairment between PD and PDD suggest that depression may not contribute to olfactory dysfunction in PD.