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Selective changes of ocular vestibular myogenic potentials in Parkinson's disease
Author(s) -
PötterNerger Monika,
Govender Sendhil,
Deuschl Günther,
Volkmann Jens,
Colebatch J.G.
Publication year - 2015
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.26114
Subject(s) - vestibular evoked myogenic potential , vestibular system , brainstem , medicine , audiology , parkinson's disease , vestibular nuclei , reflex , neuroscience , psychology , anesthesia , disease
Background Vestibular evoked myogenic potentials represent electrophysiological tools to measure vestibular reflex actions at different levels of the brainstem in Parkinson's disease. Objective To investigate cervical and ocular vestibular myogenic potentials in Parkinsonian patients with mild disability. Methods In 13 Parkinsonian patients and 13 age‐matched healthy controls, cervical and ocular vestibular myogenic potentials were recorded after unilateral air‐conducted tone bursts and bone‐conducted stimuli delivered at the forehead or mastoids. Results In contrast to relatively preserved cervical vestibular evoked myogenic potentials, ocular vestibular evoked myogenic potentials were significantly delayed and of reduced amplitude, particularly after impulsive stimulation in Parkinsonian patients. Levodopa had no significant effect on either type of response. Conclusion In mild to moderate Parkinson's disease, altered ocular vestibular myogenic potentials may indicate early functional involvement of the upper brainstem, in contrast to preserved lower brainstem function as reflected by normal cervical vestibular myogenic potentials. © 2014 International Parkinson and Movement Disorder Society