Presynaptic effects of levodopa and their possible role in dyskinesia | Zendy

Mosharov Eugene V. | Zendy; Borgkvist Anders | Zendy; Sulzer David | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Presynaptic effects of levodopa and their possible role in dyskinesia

Author(s) -

Mosharov Eugene V.,

Borgkvist Anders,

Sulzer David

Publication year - 2015

Publication title -

movement disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.352

H-Index - 198

eISSN - 1531-8257

pISSN - 0885-3185

DOI - 10.1002/mds.26103

Subject(s) - levodopa , neurotransmitter , dyskinesia , dopamine , reuptake , neuroscience , neurotransmission , dopaminergic , parkinson's disease , serotonergic , synaptic vesicle , serotonin , medicine , pharmacology , psychology , chemistry , disease , central nervous system , vesicle , biochemistry , receptor , membrane

Levodopa replacement therapy has long provided the most effective treatment for Parkinson's disease (PD). We review how this dopamine (DA) precursor enhances dopaminergic transmission by providing a greater sphere of neurotransmitter influence as a result of the confluence of increased quantal size and decreased DA reuptake, as well as loading DA as a false transmitter into surviving serotonin neuron synaptic vesicles. We further review literature on how presynaptic dysregulation of DA release after l ‐dopa might trigger dyskinesias in PD patients. © 2014 International Parkinson and Movement Disorder Society

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research