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Presynaptic effects of levodopa and their possible role in dyskinesia
Author(s) -
Mosharov Eugene V.,
Borgkvist Anders,
Sulzer David
Publication year - 2015
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.26103
Subject(s) - levodopa , neurotransmitter , dyskinesia , dopamine , reuptake , neuroscience , neurotransmission , dopaminergic , parkinson's disease , serotonergic , synaptic vesicle , serotonin , medicine , pharmacology , psychology , chemistry , disease , central nervous system , vesicle , biochemistry , receptor , membrane
Levodopa replacement therapy has long provided the most effective treatment for Parkinson's disease (PD). We review how this dopamine (DA) precursor enhances dopaminergic transmission by providing a greater sphere of neurotransmitter influence as a result of the confluence of increased quantal size and decreased DA reuptake, as well as loading DA as a false transmitter into surviving serotonin neuron synaptic vesicles. We further review literature on how presynaptic dysregulation of DA release after l ‐dopa might trigger dyskinesias in PD patients. © 2014 International Parkinson and Movement Disorder Society