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Coenzyme Q10 and spinocerebellar ataxias
Author(s) -
Lo Raymond Y.,
Figueroa Karla P.,
Pulst Stefan M.,
Lin ChiYing,
Perlman Susan,
Wilmot George,
Gomez Christopher,
Schmahmann Jeremy,
Paulson Henry,
Shakkottai Vikram G.,
Ying Sarah,
Zesiewicz Theresa,
Bushara Khalaf,
Geschwind Michael,
Xia Guangbin,
Subramony S.H.,
Ashizawa Tetsuo,
Kuo ShengHan
Publication year - 2015
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.26088
Subject(s) - spinocerebellar ataxia , coenzyme q10 , rating scale , medicine , physical therapy , disease , ataxia , psychology , physical medicine and rehabilitation , psychiatry , developmental psychology
The aim of this study was to investigate the association between drug exposure and disease severity in SCA types 1, 2, 3 and 6. The Clinical Research Consortium for Spinocerebellar Ataxias (CRC‐SCA) enrolled 319 participants with SCA1, 2, 3, and 6 from 12 medical centers in the United States and repeatedly measured clinical severity by the Scale for Assessment and Rating of Ataxia (SARA), the Unified Huntington's Disease Rating Scale part IV (UHDRS‐IV), and the 9‐item Patient Health Questionnaire during July 2009 to May 2012. We employed generalized estimating equations in regression models to study the longitudinal effects of coenzyme Q10 (CoQ10), statin, and vitamin E on clinical severity of ataxia after adjusting for age, sex, and pathological CAG repeat number. Cross‐sectionally, exposure to CoQ10 was associated with lower SARA and higher UHDRS‐IV scores in SCA1 and 3. No association was found between statins, vitamin E, and clinical outcome. Longitudinally, CoQ10, statins, and vitamin E did not change the rates of clinical deterioration indexed by SARA and UHDRS‐IV scores within 2 years. CoQ10 is associated with better clinical outcome in SCA1 and 3. These drug exposures did not appear to influence clinical progression within 2 years. Further studies are warranted to confirm the association. © 2014 International Parkinson and Movement Disorder Society