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Mortality in Parkinson's disease: A 38‐year follow‐up study
Author(s) -
Pinter Bernadette,
DiemZangerl Anja,
Wenning Gregor Karl,
Scherfler Christoph,
Oberaigner Willi,
Seppi Klaus,
Poewe Werner
Publication year - 2015
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.26060
Subject(s) - medicine , pediatrics , proportional hazards model , cohort , hazard ratio , disease , parkinson's disease , cohort study , pneumonia , confidence interval
Background In this study we report on the outcome including overall and cause‐specific mortality of Parkinson's disease (PD) patients subsequent to 38 years of surveillance. This is an extension study of our previous report on mortality. Methods Two hundred thirty‐seven patients with a symptom onset between 1974 and 1984 were followed until the date of December 31, 2012 or death, representing a follow‐up period of up to 38 years. Overall and cause‐specific standardized mortality ratios (SMRs) were calculated, and predictors for survival at disease onset were estimated. Results and Conclusion Two hundred thirty patients had died by December 31, 2012; a total of 3,489 person‐years were available for observation. The SMR at 38 years of follow‐up was 2.02 (1.76‐2.29). Employing Cox's proportional hazard modeling, male sex, gait disorder, absence of classical rest tremor, and absence of asymmetry predicted poor survival in this cohort. Increased cause‐specific SMRs were found for pneumonia and cerebrovascular and cardiovascular diseases. © 2014 International Parkinson and Movement Disorder Society