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Cognitive impairment in multiple system atrophy: A position statement by the neuropsychology task force of the MDS multiple system atrophy (MODIMSA) study group
Author(s) -
Stankovic Iva,
Krismer Florian,
Jesic Aleksandar,
Antonini Angelo,
Benke Thomas,
Brown Richard G.,
Burn David J.,
Holton Janice L.,
Kaufmann Horacio,
Kostic Vladimir S.,
Ling Helen,
Meissner Wassilios G.,
Poewe Werner,
Semnic Marija,
Seppi Klaus,
Takeda Atsushi,
Weintraub Daniel,
Wenning Gregor K.
Publication year - 2014
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.25880
Subject(s) - atrophy , dementia , neuropsychology , psychology , cognition , neuroscience , executive functions , executive dysfunction , physical medicine and rehabilitation , disease , audiology , cognitive psychology , medicine , pathology
Consensus diagnostic criteria for multiple system atrophy consider dementia as a nonsupporting feature, despite emerging evidence demonstrating that cognitive impairments are an integral part of the disease. Cognitive disturbances in multiple system atrophy occur across a wide spectrum from mild single domain deficits to impairments in multiple domains and even to frank dementia in some cases. Frontal‐executive dysfunction is the most common presentation, while memory and visuospatial functions also may be impaired. Imaging and neuropathological findings support the concept that cognitive impairments in MSA originate from striatofrontal deafferentation, with additional contributions from intrinsic cortical degeneration and cerebellar pathology. Based on a comprehensive evidence‐based review, the authors propose future avenues of research that ultimately may lead to diagnostic criteria for cognitive impairment and dementia associated with multiple system atrophy. © 2014 International Parkinson and Movement Disorder Society