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Alcohol intake and risk of Parkinson's disease: A meta‐analysis of observational studies
Author(s) -
Zhang Dongfeng,
Jiang Hong,
Xie Junxia
Publication year - 2014
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.25863
Subject(s) - medicine , confidence interval , relative risk , meta analysis , observational study , parkinson's disease , alcohol , alcohol intake , disease , biology , biochemistry
Background The association of alcohol intake with risk of Parkinson's disease remains unclear. Methods Pertinent studies were identified in PubMed and EMBASE. The fixed‐effect or random‐effect model was selected based on heterogeneity. The dose‐response relationship was assessed by restricted cubic splines. Results We included 32 articles, involving 677,550 subjects (9994 cases). The smoking‐adjusted risk of Parkinson's disease for the highest versus lowest level of alcohol intake was relative risk (RR) 0.78 (95% confidence interval [CI], 0.67‐0.92) overall, 0.86 (95% CI, 0.75‐0.995) in prospective studies, and 0.74 (95% CI, 0.58‐0.96) in matched case‐control studies. A significant association was found with beer (0.59; 95% CI, 0.39‐0.90) but not with wine and liquor, and for males (0.65; 95% CI, 0.47‐0.90) after a sensitivity analysis but not for females. The risk of Parkinson's disease decreased by 5% (0.95; 95% CI, 0.89‐1.02) for every 1 drink/day increment in alcohol intake in a linear ( P for nonlinearity = 0.85) dose‐response manner. Conclusions Alcohol intake, especially beer, might be inversely associated with risk of Parkinson's disease © 2014 International Parkinson and Movement Disorder Society