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Study of medication‐free children with Tourette syndrome do not show imaging abnormalities
Author(s) -
Jeppesen Signe Søndergaard,
Debes Nanette Mol,
Simonsen Helle Juhl,
Rostrup Egill,
Larsson H.B.W.,
Skov Liselotte
Publication year - 2014
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.25858
Subject(s) - tourette syndrome , white matter , gray (unit) , pathophysiology , psychology , tourette's syndrome , cohort , medicine , magnetic resonance imaging , neuroimaging , neuroscience , pediatrics , psychiatry , nuclear medicine , radiology
Background Imaging studies of patients with Tourette's syndrome (TS) across different cohorts have shown alterations in gray and white matter in areas associated with the cortico‐striato‐thalamic‐cortical (CSTC) pathways; however, no consistent findings have subsequently established a clear indication of the pathophysiology of TS. Methods This study was designed to investigate changes in gray and white matter in medication‐free children with TS in the CSTC areas. With MRI, 24 children with TS and 18 healthy controls were analyzed using three complementary methods. Results and Conclusion Analyses revealed no differences between controls and patients with TS in gray or white matter. Possible discrepancies between cohorts and methods may play a role in the different findings in other studies. Further studies investigating well‐defined cohorts with TS analyzing both gray and white matter in the same cohort may add additional information to the pathophysiology of TS. © 2014 International Parkinson and Movement Disorder Society