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Patterns of cortical thinning in idiopathic rapid eye movement sleep behavior disorder
Author(s) -
Rahayel Shady,
Montplaisir Jacques,
Monchi Oury,
Bedetti Christophe,
Postuma Ronald B.,
Brambati Simona,
Carrier Julie,
Joubert Sven,
Latreille Véronique,
Jubault Thomas,
Gag JeanFrançois
Publication year - 2014
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.25820
Subject(s) - white matter , rem sleep behavior disorder , parasomnia , lingual gyrus , psychology , rapid eye movement sleep , diffusion mri , polysomnography , dementia with lewy bodies , neuroscience , magnetic resonance imaging , dementia , eye movement , medicine , pathology , electroencephalography , functional magnetic resonance imaging , disease , radiology
Idiopathic rapid eye movement sleep behavior disorder is a parasomnia that is a risk factor for dementia with Lewy bodies and Parkinson's disease. Brain function impairments have been identified in this disorder, mainly in the frontal and posterior cortical regions. However, the anatomical support for these dysfunctions remains poorly understood. We investigated gray matter thickness, gray matter volume, and white matter integrity in patients with idiopathic rapid eye movement sleep behavior disorder. Twenty‐four patients with polysomnography‐confirmed idiopathic rapid eye movement sleep behavior disorder and 42 healthy individuals underwent a 3‐tesla structural and diffusion magnetic resonance imaging examination using corticometry, voxel‐based morphometry, and diffusion tensor imaging. In the patients with idiopathic rapid eye movement sleep behavior disorder, decreased cortical thickness was observed in the frontal cortex, the lingual gyrus, and the fusiform gyrus. Gray matter volume was reduced in the superior frontal sulcus only. Patients showed no increased gray matter thickness or volume. Diffusion tensor imaging analyses revealed no significant white matter differences between groups. Using corticometry in patients with idiopathic rapid eye movement sleep behavior disorder, several new cortical regions with gray matter alterations were identified, similar to those reported in dementia with Lewy bodies and Parkinson's disease. These findings provide some anatomical support for previously identified brain function impairments in this disorder. © 2014 International Parkinson and Movement Disorder Society