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Striatal dopamine D1‐like receptor binding is unchanged in primary focal dystonia
Author(s) -
Karimi Morvarid,
Moerlein Stephen M.,
Videen Tom O.,
Su Yi,
Flores Hubert P.,
Perlmutter Joel S.
Publication year - 2013
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.25720
Subject(s) - putamen , radioligand , dopamine receptor d2 , dystonia , basal ganglia , medicine , dopamine , receptor , dopamine receptor d1 , endocrinology , dopamine receptor , neuroscience , psychology , chemistry , biology , central nervous system
Background : Multiple studies have demonstrated decreases in striatal D2‐like (D2, D3) radioligand binding in primary focal dystonias. Although most investigations have focused on D2‐specific receptors (D2R), a recent study suggests that the decreased D2‐like binding may be due to a D3‐specific (D3R) abnormality. However, only limited data exist on the role of D1‐specific receptors (D1R) and the D1R‐mediated pathways within basal ganglia in dystonia. Metabolic positron emission tomography (PET) data in primary generalized dystonia suggest resting state over activity in the D1R‐mediated direct pathway, leading to excessive disinhibition of motor cortical areas. This work investigated whether striatal D1‐like receptors are affected in primary focal dystonias. Methods : Striatal‐specific (caudate and putamen) binding of the D1‐like radioligand [ 11 C]NNC 112 was measured using PET in 19 patients with primary focal dystonia (cranial, cervical, or arm) and 18 controls. Results : No statistically significant difference was detected in striatal D1‐like binding between the two groups. The study had 91% power to detect a 20% difference, indicating that false‐negative results were unlikely. Conclusions : Because [ 11 C]NNC 112 has high affinity for D1‐like receptors, very low affinity for D2‐like receptors, and minimal sensitivity to endogenous dopamine levels, we conclude that D1‐like receptor binding is not impaired in these primary focal dystonias. © 2013 International Parkinson and Movement Disorder Society