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Deep brain stimulation for gait and postural symptoms in Parkinson's disease
Author(s) -
PötterNerger Monika,
Volkmann Jens
Publication year - 2013
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.25677
Subject(s) - deep brain stimulation , pedunculopontine nucleus , subthalamic nucleus , parkinson's disease , gait , physical medicine and rehabilitation , neuroscience , substantia nigra , globus pallidus , medicine , psychology , dopaminergic , gait disturbance , dopamine , disease , basal ganglia , central nervous system , pathology
In patients with Parkinson's disease, gait and balance difficulties have emerged as some of the main therapeutic concerns. During earlier stages of the disease, the dopamine‐responsive aspects of gait disorder can be treated initially with dopaminergic drugs or deep brain stimulation. However, certain temporal aspects of parkinsonian gait disorder remain therapeutically resistant in both the short term and the long term. In this review, we summarize the effects of deep brain stimulation on gait and postural symptoms in the five currently available targets (subthalamic nucleus, globus pallidus, ventralis intermedius thalamic nucleus, pedunculopontine nucleus, and substantia nigra) and describe programming strategies for patients who are mainly disabled by gait problems. © 2013 International Parkinson and Movement Disorder Society