Premium
Subthalamus deep brain stimulation for primary dystonia patients: A long‐term follow‐up study
Author(s) -
Cao Chunyan,
Pan Yixin,
Li Dianyou,
Zhan Shikun,
Zhang Jing,
Sun Bomin
Publication year - 2013
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.25586
Subject(s) - deep brain stimulation , dystonia , subthalamic nucleus , stimulation , rating scale , movement disorders , medicine , psychology , globus pallidus , anesthesia , physical medicine and rehabilitation , neuroscience , parkinson's disease , basal ganglia , disease , central nervous system , developmental psychology
Background Deep brain stimulation has generated sustained improvement in motor function for patients with dystonia, but the long‐term impact of subthalamic nucleus stimulation on dystonia has not been elucidated. Methods Patients with primary dystonia underwent bilateral subthalamic nucleus stimulation and were evaluated with the Burke–Fahn–Marsden dystonia rating scale and the Medical Outcomes Study 36‐item Short‐Form General Health Survey at baseline and 1 month, 1 year, and 3 to 10 years postoperatively. Results Improvements in motor function according to the Burke–Fahn–Marsden dystonia rating scale at 1 month, 1 year, and 3 to 10 years of stimulation were 55%, 77%, and 79%, respectively. The quality of life improved after 1 month of stimulation ( P < 0.001), progressed within 1 year ( P < 0.001), and then remained stable. Disease duration was negatively correlated with an improvement in motor function. Conclusions Our results demonstrate that the subthalamus is an alternative to the globus pallidus internus as a target for deep brain stimulation to treat primary dystonia. © 2013 International Parkinson and Movement Disorder Society