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Questionnaire‐based diagnosis of REM sleep behavior disorder in Parkinson's disease
Author(s) -
Chahine Lama M.,
Daley Joseph,
Horn Stacy,
Colcher Amy,
Hurtig Howard,
Cantor Charles,
Dahodwala Nabila
Publication year - 2013
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.25438
Subject(s) - polysomnogram , gold standard (test) , rapid eye movement sleep , rem sleep behavior disorder , medicine , parkinson's disease , disease , physical therapy , pediatrics , psychology , psychiatry , polysomnography , apnea , electroencephalography
Background Rapid eye movement (REM) sleep behavior disorder (RBD) is present in around 40% of Parkinson's disease (PD) patients. Definitive diagnosis requires a polysomnogram, but that is costly, time intensive, and not practical for large‐scale studies. Therefore, we assessed using a questionnaire‐based diagnostic approach. Methods The patient‐administered RBD questionnaire and bed‐partner‐administered question 1 of the Mayo questionnaire were prospectively validated. Results Seventy‐five PD patients (51 male, 68 Hoehn and Yahr stages I and II) participated. Forty‐eight had a clinical history of RBD. Sensitivity was 100% (95% CI, 86.3%–100%) when a combination of both questionnaires was compared with the gold standard of polysomnogram‐confirmed RBD. Among those who achieved REM sleep (n = 65), specificity was highest for the patient questionnaire used alone, at 82.4% (95% CI, 64.8%–92.6%). Conclusions A combination of patient and bed‐partner questionnaires is a useful tool to detect RBD. © 2013 Movement Disorder Society