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Short latency afferent inhibition: A biomarker for mild cognitive impairment in Parkinson's disease?
Author(s) -
Yarnall Alison J.,
Rochester Lynn,
Baker Mark R.,
David Rachel,
Khoo Tien K.,
Duncan Gordan W.,
Galna Brook,
Burn David J.
Publication year - 2013
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.25360
Subject(s) - parkinson's disease , transcranial magnetic stimulation , dementia , cholinergic , neuroscience , medicine , latency (audio) , psychology , cognition , disease , stimulation , electrical engineering , engineering
Background Mild cognitive impairment in Parkinson's disease (PD) is common and predicts those at risk of dementia. Cholinergic dysfunction may contribute to its pathophysiology and can be assessed using short latency afferent inhibition. Methods Twenty‐two patients with PD (11 cognitively normal; 11 with mild cognitive impairment) and 22 controls participated. Short latency afferent inhibition was measured by conditioning motor evoked potentials, which were elicited by transcranial magnetic stimulation of the motor cortex with electrical stimuli delivered to the contralateral median nerve at varying interstimulus intervals. Results There was no significant difference between cognitively normal PD and controls for short latency afferent inhibition (62.8±30.3% vs. 55.7±21.7%; P =0.447). The PD‐mild cognitive impairment group had significantly less inhibition (88.4±25.8%) than both cognitively normal PD ( P =0.021) and controls ( P =0.01). Conclusions Cholinergic dysfunction occurs early in those with PD‐mild cognitive impairment. Short latency afferent inhibition may be a useful biomarker of increased risk of dementia in PD patients. © 2013 Movement Disorder Society