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Dopamine agonists and delusional jealousy in Parkinson's disease: A cross‐sectional prevalence study
Author(s) -
Poletti Michele,
Perugi Giulio,
Logi Chiara,
Romano Anna,
Del Dotto Paolo,
Ceravolo Roberto,
Rossi Giuseppe,
Pepe Pasquale,
Dell'Osso Liliana,
Bonuccelli Ubaldo
Publication year - 2012
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.25129
Subject(s) - cross sectional study , parkinson's disease , jealousy , dopamine , medicine , psychology , psychiatry , disease , psychotherapist , pathology
Background: Delusional jealousy (DJ) has been described in patients with Parkinson's disease (PD) on dopaminergic therapy, but a role for dopaminergic therapy in DJ has not been established. Methods: The current cross‐sectional study on DJ investigated its association with dopaminergic therapies compared with their associations with hallucinations and its prevalence in PD patients. Eight hundred five consecutive patients with PD were enrolled between January 2009 and June 2010. Results: DJ was identified in 20 patients (2.48%) and hallucinations in 193 patients (23.98%). In the multivariate logistic regression analyses, dopamine agonists were significantly associated with DJ (odds ratio, 18.1; 95% CI, 3.0–infinity; P = .0002) but not with hallucinations (odds ratio, 0.73; 95% CI, 0.49–1.10; P = .133). Conclusions: These findings suggest that dopamine agonist treatment represents a risk factor for DJ in PD independent of the presence of a dementing disorder, and the presence of this additional nonmotor side effect should be investigated in this clinical population. © 2012 Movement Disorder Society