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Weight variation before and after surgery in Parkinson's disease: A noradrenergic modulation?
Author(s) -
Guimarães Joana,
Moura Eduardo,
VieiraCoelho Maria Augusta,
Garrett Carolina
Publication year - 2012
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.25063
Subject(s) - locus coeruleus , subthalamic nucleus , deep brain stimulation , parkinson's disease , neuroscience , disease , medicine , psychology , central nervous system disease , stimulation , central nervous system
Changes in the nutritional profile of patients with Parkinson's disease have been reported before and after deep brain stimulation surgery. The major determinants of the weight variation in Parkinson's disease are not yet understood, and the mechanism seems complex. Based on the influence of the sympathetic nervous system in metabolic syndrome obesity, the intent of the present review is to consider the role of noradrenergic modulation on weight variations in Parkinson's disease. In this review the authors raise the following hypothesis: weight variation in Parkinson's disease before and after deep brain stimulation of the subthalamic nucleus could be influenced by noradrenergic interaction between the locus coeruleus, subthalamic nucleus, and hypothalamic nucleus. © 2012 Movement Disorder Society