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Increased medial orbitofrontal [ 18 F]fluorodopa uptake in Parkinsonian impulse control disorders
Author(s) -
Joutsa Juho,
Martikainen Kirsti,
Niemelä Solja,
Johansson Jarkko,
Forsback Sarita,
Rinne Juha O.,
Kaasinen Valtteri
Publication year - 2012
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.24941
Subject(s) - monoaminergic , orbitofrontal cortex , hypersexuality , impulse control , medicine , dopamine , psychology , impulse control disorder , striatum , psychiatry , pathological , prefrontal cortex , cognition , serotonin , receptor , disease
Background: Impulse control disorders (ICDs) occur frequently in PD patients. Methods: To investigate the possible involvement of the mesostriatal and mesolimbic monoaminergic function in ICDs associated with PD, we examined patients with (n = 10) and without (n = 10) ICDs using the brain [ 18 F]fluorodopa PET. Results: Patients with ICDs (e.g., pathological gambling, hypersexuality, and compulsive eating) showed up to 35% higher [ 18 F]fluorodopa uptake in the medial orbitofrontal cortex, compared to control patients, but no differences in the striatum. The results remained significant also after excluding subjects with comorbid psychiatric disorders. Conclusions: Increased monoaminergic activity in the medial orbitofrontal cortex might be associated with increased sensitivity for ICDs under dopamine‐replacement therapy in PD. © 2012 Movement Disorder Society