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Lewy pathology and neurodegeneration in premotor Parkinson's disease
Author(s) -
Del Tredici Kelly,
Braak Heiko
Publication year - 2012
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.24921
Subject(s) - neuropathology , neurodegeneration , hypokinesia , parkinson's disease , resting tremor , neuroscience , lewy body , chronic traumatic encephalopathy , medicine , postural instability , progressive supranuclear palsy , movement disorders , disease , amyotrophic lateral sclerosis , psychology , parkinsonism , physical medicine and rehabilitation , pathology , poison control , injury prevention , environmental health , concussion
The foremost motor manifestations of Parkinson's disease are resting tremor, cogwheel rigidity, hypokinesia/bradykinesia, and postural instability. Epidemiological and clinical data reveal that a wide variety of additional complaints (nonmotor symptoms), also considerably impar patients' quality of life parallel to the chronic‐progressive neurodegenerative disorder. This article reviews the neuropathology and anatomy of Lewy pathology‐related neurodegeneration in relation to selected nonmotro and prodromal dysfunctions. © 2012 Movement Disorder Society