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Placebo effect characteristics observed in a single, international, longitudinal study in Huntington's disease
Author(s) -
Cubo Esther,
González Miguel,
del Puerto Inés,
de Yébenes Justo Garcia,
Arconada Olga Fernández,
Gabriel y Galán José María Trejo
Publication year - 2012
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.24062
Subject(s) - placebo , huntington's disease , rating scale , disease , medicine , clinical trial , population , psychology , psychiatry , physical therapy , developmental psychology , pathology , alternative medicine , environmental health
Background: Classically, clinical trials are based on the placebo‐control design. Our aim was to analyze the placebo effect in Huntington's disease. Methods: Placebo data were obtained from an international, longitudinal, placebo‐controlled trial for Huntington's disease (European Huntington's Disease Initiative Study Group). One‐hundred and eighty patients were evaluated using the Unified Huntington Disease Rating Scale over 36 months. A placebo effect was defined as an improvement of at least 50% over baseline scores in the Unified Huntington Disease Rating Scale, and clinically relevant when at least 10% of the population met it. Results: Only behavior showed a significant placebo effect, and the proportion of the patients with placebo effect ranged from 16% (first visit) to 41% (last visit). Nondepressed patients with better functional status were most likely to be placebo‐responders over time. Conclusions: In Huntington's disease, behavior seems to be more vulnerable to placebo than overall motor function, cognition, and function © 2011 Movement Disorder Society