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Cerebrospinal fluid fatty acids in glucocerebrosidase‐associated Parkinson's disease
Author(s) -
Schmid Stefan P.,
Schleicher Erwin D.,
Cegan Alexander,
Deuschle Christian,
Baur Stephanie,
Hauser AnnKathrin,
Synofzik Matthis,
Srulijes Karin,
Brockmann Kathrin,
Berg Daniela,
Maetzler Walter
Publication year - 2012
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.23984
Subject(s) - glucocerebrosidase , parkinson's disease , cerebrospinal fluid , medicine , pathogenesis , endocrinology , disease
Background: Heterozygous mutations in the glucocerebrosidase gene lead to an increased risk for and to more severe alpha‐synuclein‐associated pathology in Parkinson's disease. As both glucocerebrosidase and alpha‐synuclein interact with fatty acids, we hypothesized that cerebrospinal fluid fatty acid levels are altered in these Parkinson's disease patients. Methods: Cerebrospinal fluid levels of 13 fatty acids in 8 Parkinson's disease patients with a heterozygous glucocerebrosidase mutation were compared with those of 41 idiopathic Parkinson's disease patients and 30 controls using gas chromatography. Results: Parkinson's disease patients with a heterozygous glucocerebrosidase mutation had lower levels of palmitoleic ( P ≤ .007), oleic ( P ≤ .016), linoleic ( P ≤ .005), arachidonic ( P ≤ .003), eicosapentaenoic ( P ≤ .003) and decosahexaenoic ( P ≤ .03) acids and lower levels of total fatty acids ( P < .005) compared with both idiopathic Parkinson's disease patients and control subjects. Conclusions: These results suggest that abnormalities of fatty acid metabolism are specifically involved in the pathogenesis of Parkinson's disease associated with a heterozygous glucocerebrosidase mutation. © 2011 Movement Disorder Society