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Fluorodeoxyglucose positron emission tomography in Richardson's syndrome and progressive supranuclear palsy‐parkinsonism
Author(s) -
Srulijes Karin,
Reimold Matthias,
Liscic Rajka M.,
Bauer Sarah,
Dietzel Elisabeth,
LiepeltScarfone Inga,
Berg Daniela,
Maetzler Walter
Publication year - 2012
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.23975
Subject(s) - progressive supranuclear palsy , parkinsonism , putamen , parkinson's disease , psychology , medicine , disease
Background: We hypothesized that postural instability and cognitive decline in patients with Richardson's syndrome could be a consequence of reduced thalamic and frontal metabolism. Severe Parkinsonian signs in patients with progressive supranuclear palsy‐parkinsonism may be reflected by alterations in putaminal metabolism. Methods: Eleven patients with Richardson's syndrome, 8 patients with progressive supranuclear palsy‐parkinsonism, 12 with Parkinson's disease, and 10 controls underwent clinical assessment and fluorodeoxyglucose positron emission tomography (PET). Results: Richardson's syndrome patients showed pronounced thalamic hypometabolism, and patients with progressive supranuclear palsy‐parkinsonism pronounced putaminal hypometabolism, compared to all other investigated groups. The putamen/thalamus uptake ratio differentiated progressive supranuclear palsy‐parkinsonism from Richardson's syndrome (area under the curve = 0.86) and from Parkinson's disease (area under the curve = 0.80) with acceptable accuracy. Frontal hypometabolism was predominantly found in Richardson's syndrome patients. Conclusions: Richardson's syndrome, progressive supranuclear palsy‐parkinsonism and Parkinson's disease showed different metabolic patterns in fluorodeoxyglucose PET. © 2011 Movement Disorder Society