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Patients with idiopathic rapid‐eye‐movement sleep behavior disorder show normal gastric motility assessed by the 13 C‐octanoate breath test
Author(s) -
Unger Marcus M.,
Möller Jens C.,
Mankel Katharina,
Schmittinger Katrin,
Eggert Karla M.,
Stamelou Maria,
StiasnyKolster Karin,
Bohne Katharina,
Bodden Maren,
Mayer Geert,
Oertel Wolfgang H.,
Tebbe Johannes J.
Publication year - 2011
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.23933
Subject(s) - gastric emptying , rapid eye movement sleep , parkinson's disease , rem sleep behavior disorder , gastroenterology , medicine , eye movement , breath test , motor disorder , sleep (system call) , movement disorders , disease , neurological disorder , central nervous system disease , stomach , psychology , computer science , ophthalmology , helicobacter pylori , operating system
Abstract Background: Delayed gastric emptying is a non‐motor symptom of Parkinson's disease. Few data exist on gastric emptying in early‐stage Parkinson's disease. In idiopathic rapid‐eye‐movement sleep behavior disorder, a presumable pre‐motor stage of Parkinson's disease, gastric emptying has not yet been investigated. Methods: Twenty healthy controls, 13 patients with idiopathic rapid‐eye‐movement sleep behavior disorder, and 39 patients with Parkinson's disease patients underwent standardized testing for gastric emptying with the 13 C‐octanoate breath test. Results: Gastric emptying was significantly delayed in drug‐naïve ( P < .001) and in treated Parkinson's disease patients ( P < .001), but normal in patients with idiopathic rapid‐eye‐movement sleep behavior disorder. Conclusions: Our study confirms delayed gastric emptying in drug‐naïve, early‐stage Parkinson's disease. Normal gastric emptying in idiopathic rapid‐eye‐movement sleep behavior disorder might be explained by the fact that neurodegenerative changes in structures modulating gastric motility are not severe enough to cause a functional deficit that can be detected by the 13 C‐octanoate breath test. © 2011 Movement Disorder Society