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Pain sensitivity and clinical progression in Parkinson's disease
Author(s) -
Mylius Veit,
Brebbermann Juliane,
Dohmann Helena,
Engau Isabel,
Oertel Wolfgang H.,
Möller Jens C.
Publication year - 2011
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.23825
Subject(s) - nociception , parkinson's disease , medicine , degenerative disease , disease , central nervous system disease , dopaminergic , anesthesia , dopamine , receptor
Pain sensitivity in Parkinson's disease is known to be altered in an L ‐dopa‐dependent manner with increased spinal nociception and experimental pain perception in the medication‐defined “off” state. As Parkinson's disease‐related pain can be an early symptom in Parkinson's disease, the present study aimed to investigate experimental pain sensitivity and spinal nociception during clinical progression. The nociceptive flexion reflex as a marker of spinal nociception as well as electrical and heat pain thresholds were assessed during the medication‐defined “off” state in 29 patients with Parkinson's disease divided into 3 severity groups (according to their Unified Parkinson's Disease Rating Scale motor score) and compared with 27 healthy elderly subjects. Parkinson's disease‐related pain was also quantified. Data provided evidence that spinal nociception and pain sensitivity are preserved during the early phase of Parkinson's disease. Following increased spinal nociception ( F 1,36 = 6.838, P = .013), experimental thermal and electrical pain sensitivity were augmented during the course of Parkinson's disease ( F 1,34 = 5.397, P = .014; F 1,34 = 6.038, P = 0.053), whereas spinal nociception further increased ( F 1,34 = 5.397, P < .001). Increased experimental pain sensitivity was observed in patients exhibiting Parkinson's disease‐related pain. Spinal alterations either on the local level or induced by diminished dopaminergic descending inhibition probably led to increased pain sensitivity in later stages. Because Parkinson's disease‐related pain is correlated with experimental pain sensitivity these 2 observations likely reflect a causal relation. © 2011 Movement Disorder Society