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Pathological gambling in Parkinson's disease—a review of the literature
Author(s) -
Djamshidian Atbin,
Cardoso Francisco,
Grosset Donald,
BowdenJones Henrietta,
Lees Andrew J.
Publication year - 2011
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.23821
Subject(s) - impulse control disorder , dopamine , pathological , parkinson's disease , disease , dopamine agonist , psychology , impulse control , medicine , hypersexuality , population , psychiatry , neuroscience , dopaminergic , environmental health
The prevalence of pathological gambling is 3.4% to 6% in treated Parkinson's disease, which is higher than the background population rate. In this review we discuss current evidence to indicate that dopamine agonists are much more likely to trigger this behavior than either L-dopa or selective monoamine oxidase B inhibitor monotherapy. New insights from recent behavioral and functional imaging studies and possible treatment approaches are also covered. A PubMed literature search using the terms "gambling" and "Parkinson's disease," "impulse control disorder," "impulsive compulsive behaviour," "dopamine agonist," of individual dopamine agonists, and of ongoing drug trials, using http://www.clinicaltrials.gov, was carried out for the period up to January 2011.