Electrogastrographyc activity in Parkinson's disease patients with and without motor fluctuations | Zendy

Albani Giovanni | Zendy; El Assawy Nadia | Zendy; Cattaldo Stefania | Zendy; De Gennaro Marilena | Zendy; Gregorini Francesca | Zendy; Pradotto Luca | Zendy; Mauro Alessandro | Zendy

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Electrogastrographyc activity in Parkinson's disease patients with and without motor fluctuations

Author(s) -

Albani Giovanni,

El Assawy Nadia,

Cattaldo Stefania,

De Gennaro Marilena,

Gregorini Francesca,

Pradotto Luca,

Mauro Alessandro

Publication year - 2011

Publication title -

movement disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.352

H-Index - 198

eISSN - 1531-8257

pISSN - 0885-3185

DOI - 10.1002/mds.23662

Subject(s) - levodopa , parkinson's disease , dopaminergic , disease , medicine , motor activity , degenerative disease , central nervous system disease , gastroenterology , psychology , physical medicine and rehabilitation , neuroscience , dopamine

Background: Gastroenteric dysfunctions are very common in Parkinson's disease, but their relationship with dopaminergic response and motor fluctuations is still unclear. Electrogastrography is a noninvasive method for measuring gastric myoelectrical activity. Methods: We evaluated the effects of levodopa intake on the motility of empty stomachs in Parkinson's disease patients with and without motor fluctuations. Results: The electrogastrography findings showed a normal pattern not influenced by levodopa intake, unrelated to plasmatic levodopa concentrations and to clinical parameters. Conclusions: Our results suggest that at rest gastric activity of Parkinson's disease patients is normal and plasmatic levodopa variability is not influenced by gastric motility. © 2011 Movement Disorder Society

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