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Electrogastrographyc activity in Parkinson's disease patients with and without motor fluctuations
Author(s) -
Albani Giovanni,
El Assawy Nadia,
Cattaldo Stefania,
De Gennaro Marilena,
Gregorini Francesca,
Pradotto Luca,
Mauro Alessandro
Publication year - 2011
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.23662
Subject(s) - levodopa , parkinson's disease , dopaminergic , disease , medicine , motor activity , degenerative disease , central nervous system disease , gastroenterology , psychology , physical medicine and rehabilitation , neuroscience , dopamine
Background: Gastroenteric dysfunctions are very common in Parkinson's disease, but their relationship with dopaminergic response and motor fluctuations is still unclear. Electrogastrography is a noninvasive method for measuring gastric myoelectrical activity. Methods: We evaluated the effects of levodopa intake on the motility of empty stomachs in Parkinson's disease patients with and without motor fluctuations. Results: The electrogastrography findings showed a normal pattern not influenced by levodopa intake, unrelated to plasmatic levodopa concentrations and to clinical parameters. Conclusions: Our results suggest that at rest gastric activity of Parkinson's disease patients is normal and plasmatic levodopa variability is not influenced by gastric motility. © 2011 Movement Disorder Society