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AFQ056 treatment of levodopa‐induced dyskinesias: Results of 2 randomized controlled trials
Author(s) -
Berg Daniela,
Godau Jana,
Trenkwalder Claudia,
Eggert Karla,
Csoti IIona,
Storch Alexander,
Huber Heiko,
MorelliCanelo Monica,
Stamelou Maria,
Ries Vincent,
Wolz Martin,
Schneider Christine,
Di Paolo Thérèse,
Gasparini Fabrizio,
Hariry Sam,
Vandemeulebroecke Marc,
AbiSaab Walid,
Cooke Katy,
Johns Donald,
GomezMancilla Baltazar
Publication year - 2011
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.23616
Subject(s) - dyskinesia , levodopa , tolerability , placebo , randomized controlled trial , rating scale , tardive dyskinesia , adverse effect , medicine , parkinson's disease , psychology , physical therapy , disease , psychiatry , schizophrenia (object oriented programming) , developmental psychology , alternative medicine , pathology
Abstract Study objectives were to assess the efficacy, safety, and tolerability of AFQ056 in Parkinson's disease patients with levodopa‐induced dyskinesia. Two randomized, double‐blind, placebo‐controlled, parallel‐group, in‐patient studies for Parkinson's disease patients with moderate to severe levodopa‐induced dyskinesia (study 1) and severe levodopa‐induced dyskinesia (study 2) on stable dopaminergic therapy were performed. Patients received 25–150 mg AFQ056 or placebo twice daily for 16 days (both studies). Study 2 included a 4‐day down‐titration. Primary outcomes were the Lang‐Fahn Activities of Daily Living Dyskinesia Scale (study 1), the modified Abnormal Involuntary Movement Scale (study 2), and the Unified Parkinson's Disease Rating Scale–part III (both studies). Secondary outcomes included the Unified Parkinson's Disease Rating Scale–part IV items 32–33. The primary analysis was change from baseline to day 16 on all outcomes. Treatment differences were assessed. Fifteen patients were randomized to AFQ056 and 16 to placebo in study 1; 14 patients were randomized to each group in study 2. AFQ056‐treated patients showed significant improvements in dyskinesias on day 16 versus placebo (eg, Lang‐Fahn Activities of Daily Living Dyskinesia Scale, P = .021 [study 1]; modified Abnormal Involuntary Movement Scale, P = .032 [study 2]). No significant changes were seen from baseline on day 16 on the Unified Parkinson's Disease Rating Scale‐part III in either study. Adverse events were reported in both studies, including dizziness. Serious adverse events (most commonly worsening of dyskinesias, apparently associated with stopping treatment) were reported by 4 AFQ056‐treated patients in study 1, and 3 patients (2 AFQ056‐treated patient and 1 in the placebo group) in study 2. AFQ056 showed a clinically relevant and significant antidyskinetic effect without changing the antiparkinsonian effects of dopaminergic therapy. © 2011 Movement Disorder Society