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Decades of delayed diagnosis in 4 levodopa‐responsive young‐onset monogenetic parkinsonism patients
Author(s) -
Ling Helen,
Braschinsky Mark,
Taba Pille,
Lüüs SiiriMerike,
Doherty Karen,
Hotter Anna,
Poewe Werner,
Lees Andrew J.
Publication year - 2011
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.23563
Subject(s) - parkinsonism , levodopa , psychogenic disease , pediatrics , movement disorders , medicine , neurological disorder , age of onset , dyskinesia , essential tremor , psychology , psychiatry , physical medicine and rehabilitation , central nervous system disease , parkinson's disease , surgery , disease
Background: We report 4 patients with young‐onset monogenetic parkinsonism, each of whom was misdiagnosed with either a psychogenic movement disorder or chronic fatigue syndrome for 10 to 23 years after the onset of their first symptoms. Results: Once the diagnosis was eventually made, they all had a rapid and excellent response to levodopa, albeit with the early appearance of interdose dyskinesias in 3. Conclusions: We discuss possible reasons for the missed diagnosis despite the relentless progression of their motor handicap. DAT scanning supported the revised clinical diagnosis of parkinsonism. © 2011 Movement Disorder Society
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