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Akinetic‐rigid and tremor‐dominant Parkinson's disease patients show different patterns of FP‐CIT Single photon emission computed tomography
Author(s) -
Eggers Carsten,
Kahraman Deniz,
Fink Gereon R.,
Schmidt Matthias,
Timmermann Lars
Publication year - 2011
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.23468
Subject(s) - putamen , parkinson's disease , single photon emission computed tomography , caudate nucleus , dopaminergic , medicine , essential tremor , rating scale , disease , cardiology , nuclear medicine , psychology , physical medicine and rehabilitation , dopamine , developmental psychology
Objective: To elucidate whether Parkinson's disease subtypes show a different pattern of Iodine‐123 fluoropropyl–;carbomethoxy‐3 β‐(FP‐CIT) single photon emission computed tomography (SPECT) binding in accordance with neuropathological findings. Methods: We analyzed a database of consecutive patients with FP‐CIT scan (n = 190) over a 3‐year period and identified 122 patients (50 women, 72 men, mean age 62 ± 11.1 years) with a diagnosis of idiopathic Parkinson's disease. Patient's characteristics and FP‐CIT scan results were analyzed and compared for the subgroups tremor‐dominant versus akinetic‐rigid and equivalent type of Parkinson's disease. Results: The analysis of all Parkinson's disease patients showed a significant difference between the FP‐CIT uptake in the subgroups tremor‐dominant and akinetic‐rigid. After matching these samples for age, disease duration, disease severity (Hoehn & Yahr grade, Unified Parkinson's Disease Rating Scale score), and levodopa‐equivalent dose, these findings were balanced between both groups (n = 23/23) without a significant difference ( P > 0.05). However, there was a clear, significant association of visually analyzed shapes of the striatum in FP‐CIT SPECT and clinical Parkinson's disease subtype. Conclusion: These results confirm neuropathological models for a reduced dopaminergic projection to the dorsal putamen in akinetic‐rigid patients as well as the lateral putamen and caudate nucleus in tremor‐dominant patients in vivo. © 2011 Movement Disorder Society